Publication Date:
1981-08-21
Description:
Ventriculocisternal administration of dl- and d-propranolol produced dose-dependent increases in cerebrospinal fluid norepinephrine and reductions in blood pressure. A highly significant correlation was found between the increase in norepinephrine and the hypotensive effect. The propranolol-induced hypotension was prevented by intracisternal phentolamine. These data indicate that the hypotensive effect of centrally administered propranolol results from a drug-induced release of norepinephrine, which stimulates central alpha receptors to lower arterial pressure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tackett, R L -- Webb, J G -- Privitera, P J -- 5T32 HL07260-02/HL/NHLBI NIH HHS/ -- GM 20387/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):911-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256285" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Pressure/*drug effects
;
Dogs
;
Injections, Intraventricular
;
Isomerism
;
Norepinephrine/*cerebrospinal fluid
;
Propranolol/administration & dosage/*pharmacology
;
Structure-Activity Relationship
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
