Publication Date:
1982-06-11
Description:
Tumors in the soft tissues of the oral cavity of rats developed at predetermined sites as a result of a combination of an intraperitoneal injection of a direct-acting carcinogen. N-nitro-N-methylurea, and a continuous irritation of the buccal mucosa by a stainless steel wire. The incidence of histologically malignant tumors was significantly higher in the irritated area than in any other area of the body. These results constitute evidence for a carcinogenic mechanism whereby the cells that develop into tumors may require the promotional effect of a nonspecific, nonmutagenic stimulus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Konstantinidis, A -- Smulow, J B -- Sonnenschein, C -- 13410/PHS HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079755" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Division
;
Cocarcinogenesis
;
Injections, Intraperitoneal
;
*Irritants
;
Male
;
Methylnitrosourea/*administration & dosage
;
Mouth Neoplasms/*chemically induced
;
Neoplasms, Experimental/chemically induced
;
Nitrosourea Compounds/*administration & dosage
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
