Publication Date:
1982-04-30
Description:
Short-term perfusion of the isolated dog gastrocnemius-plantaris muscle with hydrogen peroxide resulted in a decrease in steady-state muscle oxygen consumption and isometric tension generation. Hydrogen peroxide converted intracellular myoglobin to products incapable of combination with oxygen, but had no deleterious effect on neuromuscular transmission or on mitochondrial oxidative phosphorylation. It is concluded that functional intracellular myoglobin is important in maintaining oxygen consumption and tension generation in exercising skeletal muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cole, R P -- NHLBI-HL07018/HL/NHLBI NIH HHS/ -- NHLBI-HL24994/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):523-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071598" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Dogs
;
Hydrogen Peroxide/pharmacology
;
Mitochondria, Muscle/drug effects
;
Muscle Contraction
;
Muscles/*physiology
;
Myoglobin/*physiology
;
Oxidation-Reduction
;
Oxygen Consumption
;
*Physical Exertion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
