Publication Date:
1980-03-21
Description:
Normal ovulatory menstrual cycles were initiated in prepubertal female rhesus monkeys by the infusion of gonadotropin-releasing hormone for 6 minutes once every hou;. When this regimen was discontinued, the animals promptly reverted to an immature state. These findings permit the conclusion that neither adenohypophysial nor ovarian competence is limiting in the initiation of puberty and suggest that this process depends on the maturation of the neuroendocrine control system that directs the pulsatile secretion of gonadotropin-releasing hormone from the hypothalamus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wildt, L -- Marshall, G -- Knobil, E -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1373-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986658" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Estradiol/blood
;
Female
;
Follicle Stimulating Hormone/blood
;
Gonadotropin-Releasing Hormone/*pharmacology
;
Hypothalamus/physiology
;
Luteinizing Hormone/blood
;
Macaca/*physiology
;
Macaca mulatta/*physiology
;
Menstruation/*drug effects
;
Ovary/physiology
;
Ovulation/*drug effects
;
Pituitary Gland/physiology
;
Progesterone/blood
;
Sexual Maturation/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
