Publication Date:
1978-10-06
Description:
The effect of immune RNA treatment on the incidence of death from pulmonary metastases was studied in C57BL/6J mice after excision of a B16 murine melanoma. Immune RNA was extracted from the lymphoid tissues of guinea pigs immunized with B16 tumor and then incubated in vitro with normal C57BL/6J mouse splenocytes. Mice receiving intraperitoneal injections of these RNA-treated syngeneic splenocytes after the primary B16 isograft was resectioned showed significantly improved long-term survival (42 to 67 percent in three successive experiments) as compared to control mice (0 to 20 percent survival) receiving untreated splenocytes. The effect of RNA treatment was tumor-specific and ribonuclease sensitive. The results suggest that immunotherapy with immune RNA may be of benefit to certain patients after surgery for cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, B S -- Onikul, S R -- Mannick, J A -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):59-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694519" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Immunotherapy/methods
;
Lung Neoplasms/prevention & control
;
Lymphocytes/*immunology
;
Melanoma/immunology
;
Mice
;
Mice, Inbred C57BL
;
Neoplasm Metastasis/*prevention & control
;
Neoplasms, Experimental/immunology
;
RNA/immunology/*therapeutic use
;
Spleen/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
