Publication Date:
1981-10-02
Description:
The cationic technetium-99 complex trans-[99TC(dmpe)2Cl2]+, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH3)2P-CH2-P(CH3)2, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-(99mTc(dmpe) 2Cl2]+, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, E -- Bushong, W -- Glavan, K A -- Elder, R C -- Sodd, V J -- Scholz, K L -- Fortman, D L -- Lukes, S J -- HL-21276/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):85-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6897930" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cations, Monovalent
;
Dogs
;
Heart/*radionuclide imaging
;
*Organotechnetium Compounds
;
*Phosphines
;
Structure-Activity Relationship
;
*Technetium
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
