Publication Date:
1980-08-22
Description:
Long-term administration of either superactive analog's of gonadotropin-releasing hormone or of testosterone suppresses gonadotropin secretion in male animals and humans. Testosterone administered in combination with gonadotropin-releasing hormone analog further suppresses serum gonadotropin levels in male rats. This observation indicates synergistic activity and suggests that the gonadotropin-releasing hormone analog and testosterone act at independent sites within the hypothalamic-pituitary axis. The primary actions of superactive analog are probably mediated by changes at a postreceptor site in the pituitary gonadotropin-secreting cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heber, D -- Swerdloff, R S -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6773142" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Contraceptive Agents, Male/pharmacology
;
Dose-Response Relationship, Drug
;
Drug Synergism
;
Follicle Stimulating Hormone/*secretion
;
Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology
;
Luteinizing Hormone/*secretion
;
Male
;
Rats
;
Spermatogenesis/*drug effects
;
Testosterone/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
