Publication Date:
1982-02-19
Description:
Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from a few patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy, including Japanese adult T cell leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robert-Guroff, M -- Nakao, Y -- Notake, K -- Ito, Y -- Sliski, A -- Gallo, R C -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):975-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6760397" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Viral/*analysis
;
Antibody Specificity
;
Fluorescent Antibody Technique
;
Humans
;
Japan
;
Leukemia/*immunology
;
Radioimmunoassay
;
Retroviridae/*immunology
;
*T-Lymphocytes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
