Publication Date:
1984-08-31
Description:
The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉East, I J -- Keenan, A M -- Larson, S M -- Dean, J -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):938-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474160" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/*analysis
;
Digestive System/immunology
;
*Egg Proteins
;
Female
;
Glycoproteins/analysis/*immunology
;
Iodine Radioisotopes
;
Liver/immunology
;
Male
;
*Membrane Glycoproteins
;
Mice
;
Myocardium/immunology
;
Ovary/analysis/immunology/*radionuclide imaging
;
Ovum/*analysis
;
*Receptors, Cell Surface
;
Tissue Distribution
;
Zona Pellucida/*analysis/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
