Publication Date:
1983-03-18
Description:
Rejection of mouse pancreatic islet allografts occurred in a high percentage of donor recipient combinations identical for H-21-region antigens and differing at H-2K and H-2K + H-2D without I-region disparities. The results suggest that disparities in major histocompatibility complex antigens of class I (H-2K and H-2D) alone are capable of eliciting islet allograft rejection, and that lack of a stimulus from class II (I-region) alloantigens does not ensure permanent islet allograft survival.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morrow, C E -- Sutherland, D E -- Steffes, M W -- Najarian, J S -- Bach, F H -- AI 18326/AI/NIAID NIH HHS/ -- AI/GM 17687/AI/NIAID NIH HHS/ -- AM 13083/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6402817" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Graft Rejection
;
H-2 Antigens/*immunology
;
Histocompatibility Antigens Class II/*immunology
;
*Islets of Langerhans Transplantation
;
Major Histocompatibility Complex
;
Mice
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
