Publication Date:
1984-06-22
Description:
The human type C adenovirus E1a 13S messenger RNA encodes a gene product, that positively regulates the transcription of viral genes and certain cellular genes and is involved in the transformation of primary mammalian cells. The E1a gene product was expressed at high levels in Escherichia coli. In a Xenopus oocyte microinjection assay, the purified Escherichia coli-produced protein activated the E1a-responsive adenovirus E3 promoter and functioned as efficiently as the E1a gene itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferguson, B -- Jones, N -- Richter, J -- Rosenberg, M -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1343-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6374895" target="_blank"〉PubMed〈/a〉
Keywords:
Adenoviruses, Human/*genetics
;
Base Sequence
;
DNA, Bacterial/genetics
;
DNA, Recombinant/metabolism
;
Escherichia coli/*genetics
;
*Genes, Viral
;
Plasmids
;
RNA, Messenger/genetics
;
Viral Proteins/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
