Publication Date:
1984-05-11
Description:
An endotoxin produced by Escherichia coli caused a decrease in prolactin concentrations in the plasma of sows when given at low dosages 2 days postpartum. Five to tenfold increases occurred in the plasma cortisol concentrations. Piglet growth, used as an indicator of milk secretion by the sows, was significantly depressed after the endotoxin administration. Some cases of lactation failure in the periparturient sow may thus be due to endotoxins suppressing prolactin concentrations. This appears to be the first report of a bacterial endotoxin having an effect on prolactin in any species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B B -- Wagner, W C -- New York, N.Y. -- Science. 1984 May 11;224(4649):605-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6369541" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Endotoxins/*pharmacology
;
*Escherichia coli
;
Female
;
Lactation/drug effects
;
Lactation Disorders/etiology
;
Pregnancy
;
Prolactin/*blood
;
Swine/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
