Publication Date:
1983-04-22
Description:
With hemodialysis patients, a high serum ferritin before there was serological evidence of hepatitis B virus infection increased the likelihood that the infection would be persistent. This finding suggested that hepatitis B virus is likely to infect and actively replicate in liver cells with the propensity for increased ferritin synthesis. The virus itself could stimulate the synthesis of ferritin in a cyclic positive feedback mechanism that increases intracellular ferritin concentration and, eventually, intracellular iron. Transformed liver cells have low iron content, do not replicate hepatitis B virus, and require iron for growth. Infected, nonmalignant liver cells could supply iron to the transformed cells and nourish their expansion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lustbader, E D -- Hann, H W -- Blumberg, B S -- CA-06551/CA/NCI NIH HHS/ -- CA-22780/CA/NCI NIH HHS/ -- RR-05539/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):423-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301008" target="_blank"〉PubMed〈/a〉
Keywords:
Carcinoma, Hepatocellular/etiology
;
Carrier State/blood
;
Female
;
Ferritins/*blood
;
Hepatitis B/*blood/complications
;
Hepatitis B Surface Antigens/analysis
;
Humans
;
Iron/blood
;
Liver Neoplasms/etiology
;
Male
;
Sex Factors
;
Transferrin/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
