Publication Date:
1982-07-02
Description:
Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoshina, H -- Hortin, G -- Boime, I -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):63-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6283633" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenocorticotropic Hormone/*biosynthesis
;
Amino Acid Sequence
;
Animals
;
In Vitro Techniques
;
Kinetics
;
Leucine
;
Pituitary Gland/*metabolism
;
Pituitary Hormones, Anterior/*biosynthesis
;
Pro-Opiomelanocortin
;
Protein Precursors/*biosynthesis
;
Radioisotope Dilution Technique
;
Rats
;
Sulfur Radioisotopes
;
Sulfuric Acids/*metabolism
;
Tritium
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
