Publication Date:
1981-11-13
Description:
The metabolic and genetic factors leading to deposition of calcium pyrophosphate crystals in cartilage of patients with chondrocalcinosis are not well understood. Analysis of cultured fibroblasts and lymphoblasts from 12 affected members of a large kindred showed a mean concentration of intracellular inorganic pyrophosphate two times greater than that in cells from unaffected family members or normal, unrelated volunteers. Increased intracellular pyrophosphate may, therefore, be a biochemical marker for the heterozygous expression of the chondrocalcinosis gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lust, G -- Faure, G -- Netter, P -- Seegmiller, J E -- AM13622/AM/NIADDK NIH HHS/ -- GM17702/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):809-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270793" target="_blank"〉PubMed〈/a〉
Keywords:
Cells, Cultured
;
Chondrocalcinosis/genetics/*metabolism
;
Diphosphates/*metabolism
;
Fibroblasts/*metabolism
;
Humans
;
Lymphocytes/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
