Publication Date:
1981-07-10
Description:
Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, J -- Auersperg, N -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):218-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264597" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Transformation, Viral/*drug effects
;
Cells, Cultured
;
Epidermal Growth Factor/*pharmacology
;
Female
;
Granulosa Cells/*cytology/drug effects
;
Kirsten murine sarcoma virus/drug effects/*genetics
;
Peptides/*pharmacology
;
Rats
;
Sarcoma Viruses, Murine/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
