Publication Date:
1980-01-04
Description:
Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theoharides, T C -- Sieghart, W -- Greengard, P -- Douglas, W W -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153130" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/physiology
;
Cromolyn Sodium/*pharmacology
;
Histamine Release/*drug effects
;
Kinetics
;
Mast Cells/*drug effects/immunology/metabolism
;
Molecular Weight
;
Phosphoproteins/*metabolism
;
Phosphorylation
;
Rats
;
p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
