Publication Date:
1982-03-19
Description:
The participation of the opiate peptide enkephalin in the neural circuitry of the dorsal horn was examined at the light and ultrastructural level through the use of the combined techniques of immunocytochemistry and retrograde transport of horseradish peroxidase. Enkephalin immunoreactive axonal endings made direct synaptic contact with the soma and proximal dendrites of dorsal horn thalamic projection neurons. This observation demonstrates that one major synaptic site of enkephalin modulation of the transfer of nociceptive information in the dorsla horn is on the projection neurons themselves.U〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruda, M A -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1523-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6121374" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cats
;
Endorphins/*physiology
;
Enkephalins/*physiology
;
Horseradish Peroxidase
;
Neural Pathways/physiology
;
Neurotransmitter Agents/physiology
;
Pain/*physiopathology
;
Spinal Cord/*physiology
;
Thalamus/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
