Publication Date:
1979-03-16
Description:
A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosengarten, H -- Friedhoff, A J -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1133-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/570724" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Corpus Striatum/*drug effects/embryology/growth & development
;
Female
;
Fetus/*drug effects
;
Haloperidol/*pharmacology
;
Humans
;
*Lactation
;
Maternal-Fetal Exchange
;
Methyltyrosines/*pharmacology
;
Pregnancy
;
Rats
;
Receptors, Dopamine/*drug effects
;
Stereotyped Behavior/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
