Publication Date:
1979-10-26
Description:
Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived of food for 2, 4, 8, or 24 hours. In sheep deprived of food for 2 hours, as little as 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also decreased feeding in the 2-hour group, but only at a much higher dose range. Secretin had no effect. These findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Della-Fera, M A -- Baile, C A -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):471-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504989" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/drug effects
;
Cholecystokinin/administration & dosage/*pharmacology
;
Depression, Chemical
;
Feeding Behavior/*drug effects
;
Injections, Intraventricular
;
Pentagastrin/pharmacology
;
Peptide Fragments/pharmacology
;
Rats
;
Secretin/pharmacology
;
Sheep
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
