Publication Date:
1979-09-07
Description:
Exposure of male Charles River CDI rats to a 5% saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (less than 0.4% of the oral dose) of tritiated saccharin in vivo. No metabolites (less than 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweatman, T W -- Renwick, A G -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1019-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472722" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn/metabolism
;
*Carcinogens
;
Male
;
Rats
;
Saccharin/adverse effects/*metabolism/urine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
