Publication Date:
1979-08-31
Description:
A significant cytotoxicity index was obtained when human ovarian cancer cells in a microcytotoxicity assay were exposed during the S (DNA-synthesizing) phase of the cell cycle to purified fractions of testis exhibiting high Mullerian inhibiting substance bioactivity. The same effect was not observed when these fractions were tested against human glioblastoma or fibroblast lines. Most human ovarian cancers are said to resemble Mullerian tissues histologically. Mullerian inhibiting substance may thus deserve further study as a potential chemotherapeutic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donahoe, P K -- Swann, D A -- Hayashi, A -- Sullivan, M D -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):913-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472712" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cattle
;
Culture Techniques
;
Cystadenoma/*therapy
;
Cytotoxins/therapeutic use
;
Female
;
Humans
;
Male
;
Mullerian Ducts/*physiology
;
Ovarian Neoplasms/*therapy
;
Receptors, Drug/physiology
;
Testis/embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
