Publication Date:
1979-05-11
Description:
2-Deoxy-[14C]glucose metabolism was examined in brains of hypoxic, normotensive rats by autoradiography, which revealed alternating cortical columns of high and low metabolism. Activity in white matter was increased severalfold over that in adjacent gray matter. The columns were anatomically related to penetrating cortical arteries with areas between arteries demonstrating higher rates of metabolism. The results suggest the presence of interarterial tissue oxygen gradients that influence regional glucose metabolism. The relatively greater sensitivity of white matter metabolism to hypoxia may lead to an understanding of white matter damage in postanoxic leukoencephalopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pulsinelli, W A -- Duffy, T E -- New York, N.Y. -- Science. 1979 May 11;204(4393):626-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432667" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anoxia/*metabolism/physiopathology
;
Brain/*metabolism
;
Cerebral Cortex/metabolism
;
Cerebrovascular Circulation
;
Deoxyglucose/metabolism
;
Glucose/*metabolism
;
Male
;
Phosphorylation
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
