Publication Date:
1979-04-13
Description:
Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to 42 degrees C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, J N -- Magin, R L -- Yatvin, M B -- Zaharko, D S -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):188-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432641" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Hot Temperature
;
Liposomes/*therapeutic use
;
Male
;
Metabolic Clearance Rate
;
Methotrexate/*administration & dosage/metabolism
;
Mice
;
Neoplasms, Experimental/*drug therapy
;
Phospholipids
;
Structure-Activity Relationship
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
