Publication Date:
1985-08-16
Description:
The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nordeen, E J -- Nordeen, K W -- Sengelaub, D R -- Arnold, A P -- HD06478-02/HD/NICHD NIH HHS/ -- HD15021/HD/NICHD NIH HHS/ -- NS07355-01/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):671-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023706" target="_blank"〉PubMed〈/a〉
Keywords:
Androgens/*pharmacology
;
Animals
;
Cell Survival/drug effects
;
Female
;
Male
;
Motor Neurons/*physiology
;
Penis/innervation
;
Rats
;
*Sex Characteristics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
