Publication Date:
1986-04-11
Description:
Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity appeared to be against the anti-Id, since the anti-Id immunogen was shown to bind the chimpanzee anti-HBs. Two chimpanzees immunized with the anti-Id, along with two control animals that were either untreated or received a nonimmune rabbit immunoglobulin G preparation, were challenged with infectious hepatitis B virus. Both control chimpanzees developed clinical and serological characteristics consistent with an active hepatitis B virus infection, whereas the two anti-Id treated chimpanzees were protected from infection. Since chimpanzees provide a relevant model of a human response to hepatitis B virus immunization and infection, these results indicate that anti-Id preparations such as that described here might be candidates for vaccines against human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, R C -- Eichberg, J W -- Lanford, R E -- Dreesman, G R -- 1 P01 AI-22380-01-MID/AI/NIAID NIH HHS/ -- 1 R23 AI-22307-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 11;232(4747):220-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952505" target="_blank"〉PubMed〈/a〉
Keywords:
Alanine Transaminase/metabolism
;
Animals
;
Antibody Formation
;
Dose-Response Relationship, Immunologic
;
Hepatitis B/immunology/*prevention & control
;
Hepatitis B Antibodies/*immunology
;
Humans
;
Immunoglobulin Idiotypes/*immunology
;
Immunotherapy
;
Infant, Newborn
;
Mice
;
Pan troglodytes
;
Rabbits/immunology
;
Rats
;
Schistosoma mansoni/immunology
;
Trypanosoma/immunology
;
*Vaccines
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
