Publication Date:
1985-08-16
Description:
At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van der Ploeg, L H -- Smits, M -- Ponnudurai, T -- Vermeulen, A -- Meuwissen, J H -- Langsley, G -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):658-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3895435" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosomes/*ultrastructure
;
DNA/*isolation & purification
;
Electrophoresis, Polyacrylamide Gel/methods
;
Molecular Weight
;
Plasmodium falciparum/*genetics
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
