Publication Date:
1986-06-13
Description:
Administration of cholecystokinin (CCK) to rats caused a dose-dependent increase in plasma levels of the neurohypophyseal hormone oxytocin (OT). The OT secretion was comparable to that found in response to nausea-producing chemical agents that cause learned taste aversions. The effect of CCK on OT secretion was blunted after gastric vagotomy, as was the inhibition of food intake induced by CCK. Food ingestion also led to elevated plasma OT in rats, but CCK and aversive agents caused even greater OT stimulation. Thus, after administration of large doses of CCK, vagally mediated activation of central nausea pathways seems to be predominantly responsible for the subsequent decrease in food intake. Despite their dissimilar affective states, both nausea and satiety may activate a common hypothalamic oxytocinergic pathway that controls the inhibition of ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verbalis, J G -- McCann, M J -- McHale, C M -- Stricker, E M -- AM-16166/AM/NIADDK NIH HHS/ -- MH-25140/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1986 Jun 13;232(4756):1417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715453" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Avoidance Learning/physiology
;
Cholecystokinin/*pharmacology
;
Feeding Behavior/*physiology
;
Nausea/*physiopathology
;
Oxytocin/*secretion
;
Paraventricular Hypothalamic Nucleus/physiology
;
Rats
;
Satiation/*physiology
;
Vagotomy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
