Publication Date:
1987-05-15
Description:
Allowing mice access to food immediately after an aversive training session enhances memory retention. Cholecystokinin-octapeptide (CCK-8), which is a gastrointestinal hormone released during feeding, also enhances memory retention when administered intraperitoneally. This memory-enhancing effect of CCK-8 is blocked when the vagus nerve is cut, indicating that CCK-8 may produce its effect on memory retention by activating ascending fibers in the vagus nerve. Thus, CCK-8, a peripherally acting peptide, may mediate the memory-enhancing effects of feeding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flood, J F -- Smith, G E -- Morley, J E -- New York, N.Y. -- Science. 1987 May 15;236(4803):832-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3576201" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Avoidance Learning/drug effects
;
Electroshock
;
Male
;
Memory/*drug effects
;
Mice
;
Mice, Inbred Strains
;
Sincalide/*pharmacology
;
Vagotomy
;
Vagus Nerve/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
