Publication Date:
1978-09-15
Description:
The parasite Trypanosoma cruzi metabolizes allopurinol by a sequential conversion to allopurinol mononucleotide and aminopurinol mononucleotide. The latter is incorporated into RNA. This transformation of a widely used innocuous agent, allopurinol, into a toxic adenine analog appears to account for the antiprotozoan effect of allopurinol. These unique enzymatic activities appear to occur only in T. cruzi and the pathogenic lesihaminae. Allopurinol may serve as a model for the synthesis of similar antiprotozoan agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marr, J J -- Berens, R L -- Nelson, D J -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1018-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356267" target="_blank"〉PubMed〈/a〉
Keywords:
Adenine/pharmacology
;
Allopurinol/antagonists & inhibitors/metabolism/*pharmacology
;
Animals
;
Pyrimidine Nucleotides/antagonists & inhibitors/*biosynthesis/pharmacology
;
Ribonucleotides/antagonists & inhibitors/biosynthesis/pharmacology
;
Trypanocidal Agents/antagonists & inhibitors/*metabolism/pharmacology
;
Trypanosoma cruzi/drug effects/growth & development/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
