Publication Date:
1987-10-30
Description:
The orderly and sequential activation of genes during development is hypothesized to be related to the selective expression of groups of regulatory proteins acting primarily at the level of transcription. A nuclear protein was found in hepatocytes, but not other cell types, that binds to a sequence required for hepatocyte-specific transcription of the gene for the beta chain of fibrinogen. This protein, hepatocyte nuclear factor 1 (HNF1), also interacts with homologous sequences required for optimal promoter function of the genes for the alpha chain of fibrinogen and alpha 1-antitrypsin. The promoter or enhancer regions for several viral and cellular genes not expressed in the liver did not compete for this binding. The restricted expression of HNF1 and its selective interaction with the control regions of several liver-specific genes indicate that it is involved in developmentally regulated gene expression in the liver.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Courtois, G -- Morgan, J G -- Campbell, L A -- Fourel, G -- Crabtree, G R -- CA39612/CA/NCI NIH HHS/ -- HL33942/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1987 Oct 30;238(4827):688-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3499668" target="_blank"〉PubMed〈/a〉
Keywords:
Albumins/genetics
;
Base Sequence
;
Binding, Competitive
;
Cell Line
;
DNA-Binding Proteins/*genetics
;
Deoxyribonuclease I
;
Fibrinogen/*genetics
;
*Gene Expression Regulation
;
Liver/*physiology
;
Nuclear Proteins/*physiology
;
*Promoter Regions, Genetic
;
Regulatory Sequences, Nucleic Acid
;
Transcription Factors/*genetics
;
alpha 1-Antitrypsin/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
