Publication Date:
1978-04-07
Description:
Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B2, and the reduction of the release of lysosomal enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefer, A M -- Ogletree, M L -- Smith, J B -- Silver, M J -- Nicolaou, K C -- Barnette, W E -- Gasic, G P -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):52-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345441" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Pressure/drug effects
;
Cats
;
Coronary Circulation/drug effects
;
Coronary Disease/drug therapy
;
Epoprostenol/*pharmacology/therapeutic use
;
Heart Rate/drug effects
;
Hemodynamics/*drug effects
;
In Vitro Techniques
;
Lysosomes/drug effects/enzymology
;
Myocardial Contraction/drug effects
;
Platelet Aggregation/drug effects
;
Prostaglandins/*pharmacology
;
Thromboxanes/blood
;
Vascular Resistance/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
