Publication Date:
1978-01-20
Description:
There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmechel, D -- Marangos, P J -- Zis, A P -- Brightman, M -- Goodwin, F K -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339349" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*enzymology
;
Cross Reactions
;
Immunoenzyme Techniques
;
Isoenzymes/*metabolism
;
Liver/enzymology
;
Neuroglia/*enzymology
;
Neurons/*enzymology
;
Phosphopyruvate Hydratase/immunology/*metabolism
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
