Publication Date:
1988-05-06
Description:
The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cram, D J -- New York, N.Y. -- Science. 1988 May 6;240(4853):760-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, Los Angeles 90024.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3283937" target="_blank"〉PubMed〈/a〉
Keywords:
Acylation
;
Binding Sites
;
Chemical Phenomena
;
Chemistry
;
Crystallization
;
Enzymes
;
*Models, Chemical
;
Models, Molecular
;
Nucleic Acids
;
Thermodynamics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
