Publication Date:
1988-04-15
Description:
Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1 beta was used to stain the human brain immunohistochemically for IL-1 beta-like immunoreactive neural elements. IL-1 beta-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic neuromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breder, C D -- Dinarello, C A -- Saper, C B -- AI 15614/AI/NIAID NIH HHS/ -- HD 07009/HD/NICHD NIH HHS/ -- NS22835/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 15;240(4850):321-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Committee on Neurobiology, University of Chicago, IL 60637.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3258444" target="_blank"〉PubMed〈/a〉
Keywords:
Humans
;
Hypothalamus/*analysis/anatomy & histology/physiology
;
Immunohistochemistry
;
Interleukin-1/*analysis/immunology
;
Organ Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
