Publication Date:
1978-10-20
Description:
Tumor-promoting phorbol esters and related plant macrocyclic diterpenes inhibit the binding of epidermal growth factor to its receptors on HeLa cells. This effect shows marked structural specificity and correlates with other biological effects of these compounds on mouse skin and in cell culture systems. The active compounds inhibited binding of 125I-labeled epidermal growth factor with a 50 per-cent effective dose in the range of 10(-8) to 10(-9) M. Inhibition appears to be due to a decrease in the number of available epidermal growth factor receptors rather than a change in receptor affinity. These results suggest that certain biologic effects of tumor promoters may result from alterations in the function of cell surface receptors involved in growth regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, L S -- Weinstein, I B -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/308698" target="_blank"〉PubMed〈/a〉
Keywords:
Binding, Competitive
;
Cell Membrane/metabolism
;
Epidermal Growth Factor/*metabolism
;
HeLa Cells
;
Kinetics
;
Peptides/*metabolism
;
Phorbol Esters/*metabolism/pharmacology
;
Phorbols/*metabolism
;
Receptors, Drug/drug effects/*metabolism
;
Tetradecanoylphorbol Acetate/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
