Publication Date:
1986-07-18
Description:
Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information in the form of a variety of extracellular signals across the membrane to regulate many Ca2+-dependent processes. At an early phase of cellular responses, the enzyme appears to have a dual effect, providing positive forward as well as negative feedback controls over various steps of its own and other signaling pathways, such as the receptors that are coupled to inositol phospholipid hydrolysis and those of some growth factors. In biological systems, a positive signal is frequently followed by immediate negative feedback regulation. Such a novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to our understanding of cell-to-cell communication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishizuka, Y -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3014651" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphatases/metabolism
;
Animals
;
Blood Platelets/metabolism
;
Calcimycin/pharmacology
;
Calcium-Transporting ATPases/metabolism
;
Carrier Proteins/metabolism
;
*Cation Transport Proteins
;
Cell Membrane/physiology
;
Cyclic AMP/metabolism
;
Diglycerides/metabolism
;
Electric Conductivity
;
Enzyme Activation
;
Fluorescent Antibody Technique
;
Isoenzymes/metabolism
;
Models, Biological
;
Phosphatidylinositols/*metabolism
;
Potassium/metabolism
;
Protein Kinase C/*metabolism
;
Purkinje Cells/enzymology
;
Rats
;
Serotonin/blood
;
Sodium/metabolism
;
Sodium-Hydrogen Antiporter
;
Tetradecanoylphorbol Acetate/pharmacology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
