Publication Date:
1986-04-25
Description:
The Syrian cardiomyopathic hamster has a hereditary disease in which a progressive myocardial necrosis mimics human forms of cardiac hypertrophy. Lesions are associated with calcium overload and can be prevented with the calcium antagonist verapamil. Numbers of receptor binding sites for calcium antagonists in heart, brain, skeletal muscle, and smooth muscle were markedly increased in cardiomyopathic hamsters. The uptake of calcium-45 into brain synaptosomes was also increased in cardiomyopathic hamsters. The increase in calcium antagonist receptors and related voltage-sensitive calcium channels may be involved in the pathogenesis of this cardiomyopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wagner, J A -- Reynolds, I J -- Weisman, H F -- Dudeck, P -- Weisfeldt, M L -- Snyder, S H -- HL-17655/HL/NHLBI NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):515-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3008330" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/metabolism/physiopathology
;
*Brain Chemistry
;
Calcium/metabolism
;
Calcium Channels
;
Cardiomyopathy, Hypertrophic/*physiopathology
;
Cricetinae
;
Disease Models, Animal
;
Female
;
Heart/physiopathology
;
Male
;
Mesocricetus
;
Muscle, Smooth/analysis/metabolism
;
Muscles/*analysis/metabolism/physiopathology
;
Myocardium/*analysis/metabolism
;
Nifedipine/analogs & derivatives/metabolism
;
Nitrendipine
;
Receptors, Nicotinic/*analysis/metabolism/physiology
;
Synaptosomes/metabolism
;
Verapamil/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
