Publication Date:
1986-02-07
Description:
When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2'-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Folks, T -- Powell, D M -- Lightfoote, M M -- Benn, S -- Martin, M A -- Fauci, A S -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):600-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003906" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/genetics/microbiology
;
Cell Line
;
Deltaretrovirus/*growth & development
;
Humans
;
Idoxuridine/pharmacology
;
Models, Genetic
;
T-Lymphocytes/drug effects/*microbiology
;
Time Factors
;
*Virus Activation/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
