Publication Date:
1989-11-10
Description:
Voltage clamp recordings and noise analysis from pyramidal cells in hippocampal slices indicate that N-methyl-D-aspartate (NMDA) receptors are tonically active. On the basis of the known concentration of glutamate in the extracellular fluid, this tonic action is likely caused by the ambient glutamate level. NMDA receptors are voltage-sensitive, thus background activation of these receptors imparts a regenerative electrical property to pyramidal cells, which facilitates the coupling between dendritic excitatory synaptic input and somatic action potential discharge in these neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sah, P -- Hestrin, S -- Nicoll, R A -- MH-0037/MH/NIMH NIH HHS/ -- MH-38256/MH/NIMH NIH HHS/ -- N5-24205/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1989 Nov 10;246(4931):815-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2573153" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate/pharmacology
;
Action Potentials
;
Algorithms
;
Animals
;
Aspartic Acid/antagonists & inhibitors/metabolism
;
Extracellular Space/metabolism
;
Glutamates/*metabolism
;
Glutamic Acid
;
Hippocampus/*physiology
;
Least-Squares Analysis
;
Magnesium/pharmacology
;
Microelectrodes
;
N-Methylaspartate
;
Neurons/*physiology
;
Rats
;
Receptors, N-Methyl-D-Aspartate
;
Receptors, Neurotransmitter/*physiology
;
Synapses/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
