Publication Date:
1989-04-21
Description:
Sodium channels from diverse excitable membranes are very similar in their structure, yet surprisingly heterogeneous in their behavior. The processes that govern the opening and closing of sodium channels have appeared difficult to describe in terms of a single, unifying molecular scheme. Now cardiac sodium channels have been analyzed by high-resolution single-channel recordings over a broad range of potentials. Channels exhibited both complex and simple gating patterns at different voltages. Such behavioral diversity can be explained by the balance between two molecular transitions whereby channels can exit the open state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yue, D T -- Lawrence, J H -- Marban, E -- HL01874/HL/NHLBI NIH HHS/ -- HL36957/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Apr 21;244(4902):349-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2540529" target="_blank"〉PubMed〈/a〉
Keywords:
Electric Conductivity
;
Heart/*physiology
;
Membrane Potentials
;
Neurons/physiology
;
Probability
;
Protein Conformation
;
Sodium Channels/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
