Publication Date:
1989-03-17
Description:
Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) secretion by cultured human endothelial cells were not affected by exposure to venous shear stress (4 dynes/cm2). However, at arterial shear stresses of 15 and 25 dynes/cm2, the tPA secretion rate was 2.1 and 3.0 times greater, respectively, than the basal tPA secretion rate. PAI-1 secretion was unaffected by shear stress over the entire physiological range.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, S L -- Eskin, S G -- McIntire, L V -- HL 18672/HL/NHLBI NIH HHS/ -- HL 23016/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Mar 17;243(4897):1483-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rice University, Biomedical Engineering Laboratory, Houston, TX 77251.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2467379" target="_blank"〉PubMed〈/a〉
Keywords:
1-Methyl-3-isobutylxanthine/pharmacology
;
Cells, Cultured
;
Endothelium, Vascular/*secretion
;
Epoprostenol/pharmacology
;
Glycoproteins/secretion
;
Humans
;
Iloprost
;
In Vitro Techniques
;
Indomethacin/pharmacology
;
Plasminogen Inactivators
;
Rheology
;
Secretory Rate/drug effects
;
Stress, Mechanical
;
Time Factors
;
Tissue Plasminogen Activator/*secretion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
