Publication Date:
1988-01-29
Description:
CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyert, S M -- Ferrero, E -- Rettig, W J -- Yenamandra, A K -- Obata, F -- Le Beau, M M -- R01-AI23859/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1988 Jan 29;239(4839):497-500.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2448876" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal
;
Antigens, CD14
;
Antigens, Differentiation/*genetics/immunology
;
Cell Differentiation
;
Chromosome Mapping
;
Chromosomes, Human, Pair 5
;
DNA/genetics
;
Electrophoresis, Polyacrylamide Gel
;
Granulocytes/immunology
;
Growth Substances/*genetics
;
Humans
;
Immunosorbent Techniques
;
Leukemia/genetics
;
Macrophages/immunology
;
Mice
;
Monocytes/*immunology
;
Myelodysplastic Syndromes/genetics
;
Nucleic Acid Hybridization
;
RNA, Messenger/genetics
;
Receptors, Cell Surface/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
