Publication Date:
1985-12-20
Description:
Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations of the pregnane nucleus. These compounds are here named angiostatic steroids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crum, R -- Szabo, S -- Folkman, J -- R01-CA37395/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1375-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2416056" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Vessels/drug effects/*embryology
;
Chick Embryo
;
Drug Interactions
;
Glucocorticoids/pharmacology
;
Heparin/analogs & derivatives/*pharmacology
;
Mineralocorticoids/pharmacology
;
Neovascularization, Pathologic/*physiopathology
;
Steroids/*pharmacology
;
Structure-Activity Relationship
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
