Publikationsdatum:
1985-08-02
Beschreibung:
Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muchmore, A V -- Decker, J M -- New York, N.Y. -- Science. 1985 Aug 2;229(4712):479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409603" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
B-Lymphocytes/drug effects
;
Chromatography/methods
;
Collodion
;
Cytotoxicity, Immunologic/drug effects
;
Electrophoresis, Polyacrylamide Gel
;
Epitopes
;
Female
;
Hemolytic Plaque Technique
;
Humans
;
Immunosuppressive Agents/isolation & purification/*urine
;
In Vitro Techniques
;
Isoelectric Focusing
;
Lymphocyte Activation/drug effects
;
Molecular Weight
;
*Mucoproteins
;
Pregnancy
;
Pregnancy Proteins/isolation & purification/pharmacology/*urine
;
T-Lymphocytes/drug effects
;
Uromodulin
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
