Publication Date:
1985-07-19
Description:
Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jahnke, U -- Fischer, E H -- Alvord, E C Jr -- AM07902/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):282-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409602" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Chickens
;
Encephalomyelitis/etiology/immunology/*metabolism
;
Epitopes
;
Guinea Pigs
;
Haplorhini
;
Humans
;
Measles/metabolism
;
Myelin Basic Protein/genetics
;
Myelin P2 Protein
;
Neuritis/etiology/immunology/*metabolism
;
Rabbits
;
Rats
;
Rats, Inbred Lew
;
Viral Proteins/*genetics
;
Viral Vaccines/adverse effects/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
