Publication Date:
1990-03-30
Description:
Cytotoxic T lymphocytes (CTLs) recognize foreign peptides bound to major histocompatibility complex (MHC) class I molecules. MHC molecules can also bind endogenous self peptides, to which T cells are tolerant. Normal mice contained CTLs specific for self peptides that were from proteins of ubiquitous or tissue-restricted expression. In vivo, these endogenous self peptides are not naturally presented in sufficient density by somatic cells expressing MHC class I molecules. They can, however, be presented if added exogenously. Thus, our data imply that CTLs are only tolerant of those endogenous self peptide sequences that are presented by MHC class I-positive cells in a physiological manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schild, H -- Rotzschke, O -- Kalbacher, H -- Rammensee, H G -- New York, N.Y. -- Science. 1990 Mar 30;247(4950):1587-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2321019" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoimmunity
;
Cell Line
;
Histocompatibility Antigens Class I/*immunology
;
*Major Histocompatibility Complex
;
Mice
;
Mice, Inbred C57BL
;
Peptide Fragments/*immunology
;
T-Lymphocytes, Cytotoxic/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
