Publication Date:
1979-06-22
Description:
Male mice were given a single injection of either adrenocorticotropic hormone (ACTH) or lysine vasopressin immediately after a defeat in an encounter with an aggressive male mouse. The defeated mice were tested for submissiveness at either 24 hours, 48 hours, or 7 days after the initial encounter. Both hormone treatments increased future submissiveness, although the time courses of the effects were different: The effects of ACTH disappeared after 48 hours, whereas those of vasopressin persisted for 7 days. These results suggest that changes in peptide hormone levels following naturally stressful experiences can affect the memory of those experiences, as expressed in future adaptive responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roche, K E -- Leshner, A I -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1343-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221973" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenocorticotropic Hormone/*pharmacology
;
Aggression/*drug effects
;
Animals
;
Behavior, Animal/*drug effects
;
Humans
;
Lypressin/*pharmacology
;
Male
;
Mice
;
Stress, Psychological/physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
