Publication Date:
1979-01-26
Description:
Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelfand, E W -- Dosch, H M -- Hastings, B -- Shore, A -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):365-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/216075" target="_blank"〉PubMed〈/a〉
Keywords:
Albuterol/antagonists & inhibitors
;
Antibody Formation/*drug effects
;
Bucladesine/antagonists & inhibitors
;
Cyclic AMP/*antagonists & inhibitors
;
Humans
;
*Immunosuppression
;
Lithium/*pharmacology
;
Lymphocytes/*drug effects
;
Phosphodiesterase Inhibitors/antagonists & inhibitors
;
Phytohemagglutinins/pharmacology
;
*Rosette Formation
;
Theophylline/antagonists & inhibitors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
