Publication Date:
1978-12-08
Description:
The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Svensson, T H -- Usdin, T -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213833" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenergic Fibers/drug effects
;
Animals
;
Antidepressive Agents, Tricyclic/*pharmacology
;
Feedback
;
Locus Coeruleus/*drug effects
;
Male
;
Norepinephrine
;
Rats
;
Receptors, Adrenergic/*drug effects
;
Receptors, Adrenergic, alpha/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
